双相情感障碍临床特征与甲状腺功能变化的性别差异及其相关性

Gender difference and their correlations in clinical features and changes of thyroid function in bipolar disorder

目的分析双相情感障碍(bipolar disorder,BD)患者临床特征与治疗前后甲状腺功能的性别差异及其相关性。方法收集BD患者男、女各94、38例,分析其临床资料和甲状腺功能指标。结果患者住院时间、游离和总三碘甲状腺原氨酸(FT3、TT3)、及抗抑郁药的使用存在性别差异(P<0.05);治疗前后游离和总甲状腺素(FT4、TT4)差值的组间差异有统计学意义(P<0.05);男性中FT4差值与年龄呈负相关,发病年龄与FT4、TT4差值呈负相关,精神病性症状与FT3、FT4、TT4差值呈正相关;而女性中TT4差值与精神病性症状呈负相关。结论BD患者治疗前后的甲状腺功能及相关因素存在性别差异。

Objective To analyze the gender difference and their correlations in clinical features and changes of thyroid function in patients with bipolar disorder(BD).Methods According to gender,patients were divided into two groups(male=94,female=38).The clinical data and thyroid function indexes were collected at the beginning and end of treatment.Results At the beginning of treatment,there were significant differences in hospital stay,free and total triiodothyronine(FT3 and TT3)and the use of antidepressants between the two groups(P<0.05).There were significant differences in free and total thyroxine(TT4 and FT4)at the beginning and end of treatment(P<0.05).In males,decreasing of FT4 was negatively correlated with age.The onset age was negatively correlated with the decreasing of FT4 and TT4,and the psychotic symptoms were positively correlated with the decreasing of FT3,FT4 and TT4.In females,the decreasing of TT4 was negatively correlated with psychotic symptoms.Conclusion There are gender differences in thyroid function and related factors in BD patients the beginning and end of treatment.