1型糖尿病治疗新技术的现状与未来

Current status and future of new technologies in the treatment of type 1 diabetes

1型糖尿病(T1DM)是一种胰岛β细胞自身免疫损伤的器官特异性疾病。胰岛素治疗是T1DM最基础和最重要的治疗手段,但胰岛素治疗无法从根本上终止或者改善T1DM的主要病因——免疫调节机制紊乱。随着科技的进步,新的胰岛素与降糖药物不断研发问世为控制血糖提供了更好的手段。胰腺移植、胰岛移植、免疫治疗及细胞治疗为预防或逆转T1DM带来了希望。了解T1DM治疗新技术的现状与未来,对研究与管理T1DM患者具有十分重要的意义。

Type 1 diabetes mellitus(T1DM)is an organ-specific disease characterized by autoimmune damage to pancreaticβcells.Insulin therapy is the most basic and important treatment for T1DM,but insulin therapy cannot fundamentally terminate or improve the main cause of T1DM,namely the disorder of the immune regulation mechanism.With the advancement of science and technology,the continuous development of new insulin and hypoglycemic drugs has provided better means for glycemic control.Pancreas transplantation,islet transplantation,immunotherapy,and cell therapy have provided hope for the prevention or reversal of T1DM.It is of great significance to understand the current situation and future of new technologies for T1DM treatment for the research and management of T1DM patients.