热敏TRPV通道在特应性皮炎温热痒觉异化中的作用

The role of thermosensitive transient receptor potential vanilloid channel in the dissimilation of itching sensitized by warm in atopic dermatitis

特应性皮炎(AD)是一种以瘙痒为主要临床特点的炎症性皮肤病。瞬时感受器电位香草酸受体亚型(TRPV)通道可被不同范围的无害温度激活,在AD温热痒觉异化中扮演重要的角色。TRPV通道的抑制剂可以改善或缓解AD症状,可能作为AD治疗的新靶点。本文介绍热敏TRPV通道在AD温热痒觉异化中的作用。

Atopic dermatitis(AD)is an inflammatory skin disease characterized by itch.Transient receptor potential vanilloid(TRPV)receptor subtype channel can be activated by different ranges of harmless temperature,and plays an important role in the warm itching in AD.Inhibitors of TRPV channel can alleviate the symptoms of AD,and may be used as a new target for treatment.This paper introduces the role of thermosensitive TRPV channel in the alienation of itching sensitized by warm in AD.