慢性阻塞性肺疾病急性加重期患者血清Hcy、ApoA的表达及其与病情严重程度的相关性

Expression of serum Hcy and ApoA in patients with acute exacerbation of chronic obstructive pulmonary disease and its correlation with severity

目的观察血清同型半胱氨酸(Hcy)、载脂蛋白A(ApoA)在慢性阻塞性肺疾病急性加重期(AECOPD)患者中的表达,分析二者与AECOPD病情严重程度的关系。方法本研究为前瞻性观察性研究,纳入2019年6月至2022年5月商丘市中心医院收治的70例AECOPD患者作为研究对象,均接受对症治疗,于治疗前检测血清Hcy、ApoA水平,依据相关标准评估患者病情严重程度并进行分组,比较重症组和非重症组患者的基线资料及血清Hcy、ApoA水平,分析血清Hcy、ApoA水平与AECOPD病情严重程度的关系。结果70例AECOPD患者中重症23例(32.86%),非重症47例(67.14%)。重症组血清Hcy水平高于非重症组,血清ApoA水平低于非重症组(P<0.05),组间其他基线资料比较差异未见统计学意义(P>0.05)。Pearson相关性检验结果显示,血清Hcy水平与AECOPD患者病情严重程度呈正相关(r=0.62,P<0.001),血清ApoA水平与AECOPD患者病情严重程度呈负相关(r=-0.62,P<0.001),血清Hcy水平与ApoA水平呈负相关(r=-0.46,P<0.001)。Logistic回归分析结果显示,高血清Hcy水平、低血清ApoA水平均是AECOPD病情严重的风险因子(P均<0.05)。结论血清Hcy、ApoA水平与AECOPD病情严重程度有一定关系,且高血清Hcy水平、低血清ApoA水平的AECOPD患者病情越严重。

Objective To observe the expression of serum homocysteine(Hcy)and apolipoprotein A(ApoA)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and analyze the relationship of these indexes with the severity of AECOPD.Methods This study was a prospective observational study.Seventy AECOPD patients admitted to Shangqiu Central Hospital from June 2019 to May 2022 were included as the study subjects.All of them received symptomatic treatment,and the levels of serum Hcy and ApoA were detected before treatment.According to the relevant criteria,the severity of patients’condition was assessed,and the patients were divided into two groups.The baseline data and levels of serum Hcy,ApoA in severe group and non severe group were compared,and the relationship of levels of serum Hcy and ApoA with the severity of AECOPD was analyzed.Results Among the 70 patients with AECOPD,23 cases(32.86%)were severe and 47 cases(67.14%)were non severe.The serum Hcy level in severe group was higher than that in non severe group,and the serum ApoA level was lower than that in non severe group(P<0.05).There was no statistical significant difference in other baseline data between the two groups(P>0.05).Results of Pearson correlation test showed that the serum Hcy level was positively correlated with the severity of AECOPD patients(r=0.62,P<0.001),and the serum ApoA level was negatively correlated with the severity of AECOPD patients(r=-0.62,P<0.001),and there was a negative correlation between serum Hcy level and ApoA level(r=-0.46,P<0.001).Results of Logistic regression analysis showed that high serum Hcy level and low serum ApoA level were risk factors for severity AECOPD(P<0.05).Conclusions The levels of serum Hcy and ApoA have a certain relationship with the severity of AECOPD,and AECOPD patients with high serum Hcy level and low serum ApoA level have worse disease severity.