尿激酶致血压升高

Elevated blood pressure caused by urokinase

1例80岁男性下肢动脉硬化闭塞症患者接受尿激酶2万U/h溶栓治疗。治疗前患者血压126/66 mmHg(1 mmHg=0.133 kPa), 治疗6 h血压升至224/131 mmHg。予乌拉地尔40 mg/h微量注射泵泵入, 1 h后血压仍为200/91 mmHg。将尿激酶减量至最小维持剂量(4 000 U/h)后血压下降至150/80 mmHg。按原剂量重启尿激酶溶栓治疗2.5 h后, 血压再次升高。停用尿激酶, 血压下降至160/97 mmHg并维持稳定, 此后未再出现血压升高情况。

An 80-year-old male patient with lower extremity atherosclerosis obliterans received urokinase 20000 U/h for thrombolytic therapy.His blood pressure before the treatment was 120/60 mmHg.Blood pressure increased progressively to 224/131 mmHg after 6 hours of thrombolysis.Urapidil 40 mg/h was given by microinjection pump and blood pressure was 200/91 mmHg 1 hour later.The blood pressure decreased to 150/80 mmHg after reducing the urokinase to the minimum maintenance dose of 4000 U/h.The blood pressure rose again 2.5 hours after the original dose of urokinase was given again.After stopping urokinase again,the blood pressure decreased to 160/97 mmHg and remained stable.Since then,there was no increase in blood pressure.