中医药综合治疗糖尿病肾病合并高血压患者的临床观察

Clinical observation on comprehensive treatment of diabetes nephropathy with hypertension by traditional Chinese Medicine

目的中西医综合治疗糖尿病肾病合并高血压的临床价值。方法选取2021年7月-2022年6月在房山医院月华分院就诊的156例糖尿病肾病合并高血压的患者为观察对象。按照随机数字表法1∶1将全部患者分成两组进行随机对照临床观察。对照组(n=78)给予常规西医药治疗,观察组(n=78)在对照组治疗的基础上加用中医药治疗(中西医综合干预)。治疗1个月后,比较两组患者的疗效(空腹血糖、收缩压、舒张压)、肾功能指标(BUN、SCr、CCr、UAE)变化、并发症(头晕、恶心)发生率、中医证候积分变化(包括倦怠乏力、肢体麻木、食少纳呆、气短懒言、头昏头痛、腰痛)。结果观察组血压控制效果优于对照组,肾功能指标、中医证候积分改善优于对照组,并发症发生率低于对照组(均P<0.05)。结论中西医综合干预可有效控制糖尿病肾病患者的血糖、血压,降低并发症发生率,改善中医证候,延缓肾实质病变进展。

Objective To evaluate the clinical value of integrated traditional Chinese and western medicine in the treatment of diabetic nephropathy with hypertension.Methods From July 2021 to June 2022,156 patients with diabetes nephropathy combined with hypertension were included in Yuehua branch of Fangshan hospital.All patients were divided into 2 groups according to the method of random number table 1∶1 for randomized controlled clinical observation.The control group(n=78)was treated with conventional western medicine,while the observation group(n=78)was treated with traditional Chinese medicine on the basis of the control group(integrated intervention of traditional Chinese and western medicine).After one month of treatment,compare the curative effect(fasting blood glucose,systolic blood pressure,diastolic blood pressure),changes in renal function indicators(BUN,SCr,CCr,UAE),incidence of complications(dizziness,nausea),and changes in TCM syndrome scores(including fatigue,limb numbness,anorexia,shortness of breath,headache,back pain)of the two groups of patients.Results The control effect of blood pressure in the observation group was better than that in the control group,the improvement of renal function index and TCM syndrome score were better than that in the control group,and the incidence of complications was lower than that in the control group(all P<0.05).Conclusions The comprehensive intervention of Chinese and Western medicine can effectively control blood glucose and blood pressure of patients with diabetes nephropathy,reduce the incidence of complications,improve TCM syndromes,and delay the progression of renal parenchymal lesions.