甲型流感病毒基质蛋白M1的研究进展

Advances of influenza A virus matrix protein 1

基质蛋白1(matrix protein 1,M1)提供了甲型流感病毒蛋白之间一个相互作用的“平台”。M1不仅维持了病毒粒子的形态和表面蛋白的稳定,而且还将8个分节段的基因组固定在病毒的核心位置,最终协调病毒的高效组装和出芽。由于M1的高度保守性,研究人员对其关注度相对较低。为此,对M1的结构和功能进行了详实的回顾,并展望了M1作为新型抗病毒药物靶点的潜能。通过对甲型流感病毒M1的深入理解,以期提高我们对其他病毒基质蛋白的关注度和研究兴趣。

Matrix protein 1(M1)provides a platform for protein interactions of influenza A virus.M1 not only maintains the morphology of viral particle and the stability of surface proteins,but also anchors the eight segmented genomes at the core of virus,which ultimately coordinates efficient viral assembly and budding.Due to its highly conserved nature,relatively little attention has been paid to M1 by researchers.In this paper,we provide an informative review of the structure and function of M1 and look forward to the potential of M1 as a novel antiviral drug target.By gaining insight into M1 of influenza A virus,we aim to increase our attention and research interest in other viral matrix proteins.