摘要
癫痫是临床常见的神经系统疾病,发病机制尚未阐明,抗癫痫发作药物是主要治疗方法,其本质是抗癫痫发作而非改善癫痫疾病。本文依照“过去”、“现在”、“未来”的时间顺序,从药代动力学、药理学机制、适应证、疗效、不良反应等方面综述抗癫痫发作药物的发展历程并展望未来发展方向,为癫痫的预防与治疗提供依据。
Epilepsy is a common clinical neurological disease, the pathogenesis of which has not yet been elucidated. As the main treatment, antiepileptic seizure medicine(ASM) fights against seizures rather than improve epilepsy. According to the chronological order of "past", "present" and "future", this article reviews the development history of ASM from the aspects of pharmacokinetics, pharmacological mechanism, indications, efficacy and adverse reactions, and looks forward to the future development direction. It can provide a theoretical basis for the prevention and treatment of epilepsy.
作者
史向松
宋苏蒙
徐建洋
SHI Xiang-song;SONG Su-meng;XU Jian-yang(Department of Neurology,Huai'an No.3 People's Hospital,Huai'an 223001,Jiangsu,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2023年第2期78-88,共11页
Chinese Journal of Contemporary Neurology and Neurosurgery
基金
江苏省淮安市自然科学研究计划项目(项目编号:HAB202045)。
关键词
癫痫
抗惊厥药
医学史
综述
Epilepsy
Anticonvulsants
History of medicine
Review
