经颅直流电刺激治疗难治性癫痫研究进展

Recent advances on transcranial direct current stimulation in intractable epilepsy

经颅直流电刺激(tDCS)作为一种新兴的非侵入性神经调控技术,安全性较高,为无手术适应证或无法手术获益的难治性癫痫患者提供了选择,其中,阴极经颅直流电刺激通过抑制皮质兴奋性,恢复脑功能网络平衡,减少痫样放电和癫痫发作频率。但是由于各项研究之间存在异质性,其在癫痫治疗中的应用有待进一步探索。本文综述经颅直流电刺激原理及其治疗癫痫的潜在机制,以及近3年在癫痫临床应用中的进展,为经颅直流电刺激应用于难治性癫痫临床治疗的潜力和安全性提供依据。

Transcranial direct current stimulation(t DCS), as an emerging non-invasiveneuromodulation technology, has high safety and provides a choice for intractable epilepsy patients withoutsurgical indications or unable to benefit from surgical treatment. Among them, negative electrode t DCS canreduce epileptic discharge and seizure frequency by inhibiting abnormal cortical excitation in epilepsypatients, restoring the balance of brain functional network. However, due to the heterogeneity among theresults of various studies, its application in the treatment of epilepsy still needs further exploration. Thisarticle reviews the principle of t DCS, its potential mechanism in the treatment of epilepsy and its clinicalapplication in intractable epilepsy in the past three years, providing evidence for the potential and safety oft DCS in the clinical treatment of intractable epilepsy.