摘要
Hearing impairment constitutes a global public health problem with severe social,political,and economic consequences,and the World Health Organization estimates that about 466 million individuals globally have some degree of hearing loss.Genetic factors account for about half of all deafness cases.Currently,more than 100 genes are known to be involved in hearing loss,but the underlying molecular mechanisms behind these deafness genes have not been fully characterized.The main clinical treatment for deafness is hearing aids and cochlear implants,but their efficacy depends heavily on the quantity and quality of residual hair cells(HCs)and spiral ganglion neurons and has only limited auditory effects.
基金
supported by grants from the National Key R&D Program of China(2017YFA0105201,2021YFA1101300,2020YFA0112503)
the Strategic Priority Research Programof the Chinese Academy of Science(XDA16010303)
the National Natural Science Foundation of China(82030029,81970882,81900941,82171144,82192862,81970884,81771019)
the Natural Science Foundation from Jiangsu Province(BE2019711,BK20190121)
the China Postdoctoral Science Foundation(2020M681555)
theOutstanding Youth ProgramofNanjing Municipal Health Commission(JQX20003)
the Science and Technology Department of Sichuan Province(2021YFS0371)
the Shenzhen Fundamental Research Program(JCYJ20190814093401920,JCYJ20210324125608022)
the Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(SKLGE-2109).
