群体感应系统对牙周致病菌影响的研究进展

Research progress of research on the effect of quorum⁃sensing system on periodontal pathogens

牙周炎是人类最好发的口腔疾病之一,牙菌斑细菌作为牙周炎的始动因子,是导致牙周炎的首要因素。群体感应系统依靠群体感应信号分子调节不同种类细菌之间的通信,加强细菌之间的交流,促进疾病的发生发展。群体感应系统亦对牙菌斑细菌形成生物膜起到重要的促进作用。近年来,许多研究表明群体感应抑制剂可以有效减弱细菌间的群体感应并抑制和降低细菌生物膜的形成和毒力因子的表达。该文就群体感应系统对牙周炎致病菌影响的研究进展进行综述。

Periodontitis is one of the most common oral diseases in humans.As the initiating factor of periodontitis,dental plaque bacteria,is the primary factor leading to periodontitis.Quorum⁃sensing system relies on quorum⁃sensing signaling molecules to regulate and strengthenthe communication between different kinds of bacteria,strengthen the communication between bacteria,and promote the occurrence and development of diseases.Quorum⁃sensing system also plays an important role in promoting the formation of dental plaque biofilm by dental plaque bacteria.In recent years,many studies have shown that quorum⁃sensing inhibitors can effectively attenuate quorum sensing between bacteria and inhibit and reduce the formation of plaque biofilms between bacteria and the expression of their virulence factors.In this paper,we will review the progress of research on the effects of quorum⁃sensing signaling molecules on peri⁃odontitis pathogens.