非编码RNA在利什曼病中的调控作用研究进展

Research advances in the regulatory role of non-coding RNA in leishmaniasis

利什曼原虫可寄生于人或动物的巨噬细胞中,其引起的利什曼病是一种被忽视的热带病,据估计每年死亡人数高达4万人。非编码RNA(ncRNA)是一种不被翻译成蛋白质的基因组转录本,在多种疾病的发生发展过程中起重要的调控作用,在炎症和免疫应答中尤其突出。目前对于ncRNA在利什曼病中作用机制的研究相对较少,已有的研究表明,在利什曼原虫感染宿主初期,ncRNA通过调节抗原呈递、免疫应答、细胞自噬、细胞凋亡等过程,对原虫在宿主体内的增殖和感染起调节作用。本文对ncRNA在利什曼病中的作用机制进行综述,为利什曼病的预防、诊断和治疗提供参考。

Leishmania,which can parasitize in the macrophages of humans and animals,causing leishmaniasis,a neglected tropical disease that is estimated to kill up to 40000 people each year.Non-coding RNA(ncRNA)is a genomic transcript that is not translated into proteins,and plays an important regulatory role in the occurrence and development of a variety of diseases,especially in inflammatory and immune responses.At present,there are few studies on the mechanism of action of ncRNA in leishmaniasis,and the existing studies have shown that in the early stage of Leishmania infection with the host,ncRNA plays an important regulatory role in regulating the proliferation of the parasites in the host and the establishment of infection by regulating antigen presentation,immune response,autophagy,apoptosis.This article reviews the mechanism of action of ncRNA in leishmaniasis,which is critical for the prevention,diagnosis and treatment of leishmaniasis.