基于TLR4-NF-κB/MAPK-炎症轴的槐果碱药理作用研究进展

Research Progress on Pharmacological Effects of Sophocarpine Based on TLR4-NF-κB/MAPK-Inflammatory Axis

槐果碱为喹诺里西啶类生物碱,是从豆科槐属植物苦参、山豆根等中草药中提取而来。研究表明,槐果碱在多种疾病的进展中能抑制TLR4-NF-κB/MAPK通路,减少各类炎症因子如IL-6、IL-1β、IL-8、TNF-α、PGE2和MCP-1等的释放,调节免疫细胞的分泌,抵抗炎症对机体的损害,进而发挥保护肝脏、改善心血管和抗自身免疫性疾病等多种药理作用。基于TLR4-NF-κB/MAPK-炎症轴对近年来槐果碱的多种药理作用作以综述,以期为槐果碱新药进一步研究提供参考。

Sophocarpine is a quinolizidine alkaloid,which is extracted from Chinese herbal medicines such as Sophora flavescens Ait and Sophorae Tonkinensis Radix et Rhizoma.Studies have shown that sophocarpine can inhibit TLR4-NF-B/MAPK pathway,reduce various inflammatory factors such as IL-6,IL-1β,IL-8,TNF-α,PGE2 and MCP-1,regulate the secretion of immune cells,resist the damage of inflammation to the body,and then play a variety of pharmacological effects,such as protecting liver,improving cardiovascular system and anti-autoimmune diseases.Therefore,based on the TLR4-NF-κB/MAPK-inflammatory axis,the various pharmacological effects of sophocarpine in recent years were reviewed,in order to provide reference for new drug development and clinical application.