糖尿病前期的体质分布及客观指标相关性研究

A Study on Physical Constitution Distribution and Correlation of Objective Indicators of Prediabetes

目的:通过观察糖尿病前期体质类型分布与客观指标的相关性,探讨糖尿病前期的相关风险因素,以求找到可能延缓糖尿病前期的干预方法。方法:选取2015年1月1-日2021年12月31日于贵州中医药大学第一附属医院体检的65岁以上人群11155例,纳入糖尿病前期人群420例,对其中医体质及相关指标:腰围、血压、体质指数(BMI)、血脂、肝功能等资料进行统计学分析。结果:常见体质类型为痰湿质(41.9%)、平和质(32.1%)。痰湿质的舒张压、BMI、腰围及丙氨酸转氨酶(ALT)高于平和质,并且超重、肥胖、中心性肥胖及脂肪肝的发生率高于平和质,差异具有统计学意义(P<0.05)。平和质的总胆固醇(TC)较痰湿质高,差异有统计学意义(P<0.05)。logistic回归分析结果显示:肥胖为痰湿质糖尿病前期人群的危险因素。结论:痰湿质是糖尿病前期的易患风险因素;糖尿病前期的痰湿体质人群相较其他体质有较高的肥胖、脂肪肝患病风险;通过改善痰湿体质可能延缓糖尿病前期发病进程。

Objective:To discuss the risk factors of prediabetes by observing the distribution of physical constitution types and the correlation of objective indicators,in order to study the possible intervention methods to delay prediabetes.Methods:A total of 11155 patients over 65 years old who underwent physical examination in the First Affiliated Hospital of Guizhou University of Chinese Medicine from January 1,2015 to December 31,2021 were selected and 420 patients with prediabetes were included.The constitution of TCM and related indexes:waist circumference,blood pressure,body mass index(BMI),blood fat,liver function and other data were statistically analyzed.Results:The common constitution types were phlegm-dampness type(41.9%)and the mild type(32.1%).The diastolic blood pressure,BMI,waist circumference and alanine aminotransferase(ALT)of phlegm-dampness group were higher than those of the mild group,and the incidence of overweight,obesity,central obesity and fatty liver was higher than that of the mild group.The difference was statistically significant(P<0.05).The total cholesterol(TC)of the mild type was higher than that of the phlegm-dampness type,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that obesity was a risk factor for phlegm-dampness prediabetes.Conclusion:Phlegm-dampness is a risk factor for prediabetes.People with phlegm-dampness constitution of prediabetes have a higher risk for obesity and fatty liver than people with other constitutions.Improving phlegm-dampness constitution may delay the progression of prediabetes.