介孔二氧化硅/石墨烯复合纳米片的制备及其医疗应用

Preparation of Mesoporous Silica/Graphene Composite Nanosheets and Its Medical Application

肿瘤是目前人类生命健康最大的威胁之一,越来越多的纳米级药物运输体系被应用到肿瘤的治疗中。文章通过化学氧化法制备性石墨烯纳米粒片,以正硅酸四乙酯(TEOS)为硅源,十六烷基三甲溴化铵(CTAB)为模板,氢氧化钠为碱源,制备了介孔硅包覆的石墨烯纳米片,可用于装载化疗药物阿霉素(DOX)。通过扫描电镜和透射进行表征,结果制备的介孔二氧化硅/石墨烯复合纳米片大小均一,分散性良好,为纳米药物运输提供了理论支持。

Tumor is one of the biggest threats to human life and health at present.More and more nanoscale drug delivery systems are applied to tumor treatment.In this paper,graphene nanoparticles coated with mesoporous silicon were prepared by chemical oxidation method,using tetraethyl orthosilicate(TEOS)as the silicon source,cetyltrimethylammonium bromide(CTAB)as the template,and sodium hydroxide as the base source.The graphene nanoparticles coated with mesoporous silicon could be used to load the chemotherapy drug doxorubicin(DOX).By scanning electron microscopy(SEM)and transparent electron microscopy(TEM).Results The prepared mesoporous silica/graphene composite nano sheets were uniform in size and well dispersed,providing theoretical support for nano drug transport.