预后营养指数与老年女性冠心病人群发生骨质疏松症的关联性及预测价值

Correlation between Prognostic Nutritional Index and Osteoporosis and its Predictive Value for Osteoporosis in an Elderly Female Coronary Heart Disease Population

目的 分析预后营养指数(prognostic nutritional index,PNI)与老年女性冠心病人群发生骨质疏松症(osteoporosis,OP)的关联性及其预测价值。方法 收集2019年6月至2022年2月就诊于石家庄市人民医院和石家庄市第五医院的181例老年女性冠心病病人的临床资料,根据是否合并OP分为OP组和对照组。先后通过单因素分析和多因素Logistic回归分析PNI对老年女性冠心病人群患OP的影响,分析PNI与骨密度的相关性,采用ROC曲线分析PNI对OP的预测价值。结果 在老年女性冠心病人群中,PNI≥45是发生OP的保护因素(P<0.05);PNI与骨密度值呈线性相关(r=0.538,P<0.001)。根据ROC曲线:相对无PNI模型,含PNI模型的曲线下面积(AUC)增加了0.0453(P<0.05)。结论 PNI是老年女性冠心病人群中发生OP的独立影响因素,且与骨密度相关,对OP的发生有预测价值;PNI可能对于OP和冠心病的协同防治有临床意义。

Objective To analyze the correlation between prognostic nutritional index(PNI)and osteoporosis(OP)in elderly female with coronary heart disease and its predictive value.Methods The clinical data of 181 elderly female patients with coronary heart disease who admitted to Shijiazhuang People's Hospital and Shijiazhuang Fifth Hospital for treatment from June 2019 to February 2022 were collected,and the patients were divided into OP group and control group according to whether they had combined OP.The effect of PNI on OP in elderly women with coronary heart disease was analyzed by univariate analysis and multifactorial Logistic regression.The correlation between PNI and bone mineral density was analyzed,and the predictive value of PNI in OP was analyzed by ROC curve.Results PNI≥45 was a protective factor for the development of OP(P<0.05)in elderly women with coronary heart disease.PNI was linearly correlated with bone mineral density(r=0.538,P<0.001).The ROC curve showed relative to the model without PNI,the AUC increased by 0.453 in the model with the addition of PNI(P<0.05).Conclusion PNI is an independent influencing factor of OP in elderly women with coronary heart disease,and is related to bone mineral density,which has predictive value in the occurrence of OP.PNI may have clinical significance for the cooperative prevention and treatment of OP and coronary heart disease.