颈段食管癌的研究进展

Research Progress of Cervical Esophageal Cancer

颈段食管癌是指从食管入口至胸骨切迹的一段食管病变,周围毗邻重要器官,特别与血管、甲状腺、气管关系密切。对于局部晚期不可切除的颈段食管癌,目前治疗的首选方案是根治性放化疗,然而其远期治疗效果不能令人满意。对于局部晚期可切除的颈段食管癌,单纯手术治疗的远期生存与根治性放化疗相比无明显差异,且单纯手术治疗患者的生活质量并不优于根治性放化疗。随着新辅助治疗联合手术治疗模式的出现,颈段食管癌的远期生存明显改善。目前随着微创手术技术的进步、放疗模式的改进、免疫治疗时代的到来,明显提高了患者生存质量和远期生存率。本文主要对颈段食管癌的最新治疗进展做一综述。

Cervical esophageal carcinoma refers to a segment of esophageal lesion from the entrance of the esophagus to the sternal notch,adjacent to important organs,especially closely related to blood vessels,thyroid and trachea.For locally advanced unresectable cervical esophageal cancer,radical radiotherapy and chemotherapy is the first choice for treatment at present,but its long-term treatment effect is not satisfactory.For locally advanced resectable cervical esophageal cancer,there is no significant difference in long-term survival between surgery alone and radical radiotherapy and chemotherapy,and the quality of life of patients with surgery alone is not superior to radical radiotherapy and chemotherapy.With the emergence of new adjuvant therapy combined with surgery,the long-term survival of cervical esophageal cancer has improved significantly.At present,the progress of minimally invasive surgery technology,the improvement of radiotherapy mode,and the arrival of the era of immunotherapy have significantly improved the quality of life and long-term survival rate of the patients.This article reviews the latest progress in the treatment of cervical esophageal cancer.