肿瘤免疫治疗耐药机制与克服策略

Mechanism and respone strategies of resistance in tumor immunotherapy

免疫治疗已成为肿瘤治疗的主要手段之一,但耐药率高是限制其临床应用的主要因素。尽管大量研究已揭示了免疫治疗耐药发生的众多机制,但面对错综复杂的肿瘤免疫微环境,仍是冰山一角。如何判定不同肿瘤类型免疫治疗耐药的主要机制,并精准制定逆转免疫治疗耐药的高效策略是当前肿瘤免疫治疗领域亟需解决的关键问题。本文系统阐述免疫治疗耐药机制及应对策略的相关研究进展,以期为临床清晰地认识免疫治疗耐药发生过程,以及发掘新型逆转耐药策略提供新的思路。

Immunotherapy is a major strategy of antitumor therapy,whereas it still faces many challenges in clinical application.Although a large number of studies have revealed numerous mechanisms for the occurrence of immunotherapy resistance,it is still the tip of the iceberg in the face of the complex immune microenvironment.How to determine the main mechanisms of immunotherapy resistance in different tumor types and developing efficient strategies for reversing immunotherapy resistance are key issues that need to be addressed in the field of current tumor immunotherapy.Systematically discuss the research progress of immunotherapy resistance mechanisms and response strategies,in order to provide new ideas for better clinical understanding of the process of immunotherapy resistance and discovering novel reversal strategies.