冠状动脉内皮细胞线粒体损伤在心肌梗死中的研究进展

Mitochondrial Injury of Coronary Endothelial Cells in Myocardial Infarction

心血管疾病严重影响人们健康。心血管疾病中的心肌梗死严重危及生命。研究表明,冠状动脉内皮细胞的损伤会加重心肌梗死,而内皮细胞线粒体在内皮细胞损伤中扮演了重要角色,因此内皮细胞线粒体的研究也越来越受到人们关注。现就冠状动脉内皮细胞线粒体的结构及其损伤在氧化应激、炎症、动脉粥样硬化和心肌梗死后缺血再灌注损伤方面的研究进展和治疗进行综述,以期为心肌梗死的相关研究及治疗提供参考。

Cardiovascular disease seriously affects people’s health.Myocardial infarction in cardiovascular disease is seriously life-threatening.Studies have shown that damage to coronary endothelial cells can aggravate myocardial infarction,and endothelial cell mitochondria play an important role in endothelial cell damage,so the study of endothelial cell mitochondria has also attracted more and more attention.This article reviews the research progress and treatment of the mitochondrial structure of coronary endothelial cells and its quality control damage in oxidative stress,inflammation,atherosclerosis and ischemia reperfusion injury during myocardial infarction,in order to provide reference for the related research and treatment of myocardial infarction.