肠道菌群与肥胖的关系研究进展

The Relationship Between Intestinal Flora and Obesity

肥胖是一个威胁人类健康的全球性问题,其发病率不断上升,会导致2型糖尿病、冠心病、高血压和癌症等。肥胖的形成机制尚不完全清楚,然而肠道菌群是导致肥胖的原因之一。肠道菌群种类多样、作用复杂,其与肥胖的关系被广泛研究,肠道菌群能通过各种机制促进肥胖的发展。现就近几年对肠道菌群与肥胖的关系及肠道菌群导致肥胖的机制做一综述,并对目前基于肠道菌群为干预靶点进行预防治疗肥胖的进展进行简单的梳理。

Obesity is a global problem threatening human health.Its incidence rate is rising,which will lead to type 2 diabetes,coronary heart disease,hypertension and cancer.The formation mechanisms of obesity are not completely clear,however,intestinal flora is one of the causes of obesity.The relationship between intestinal flora and obesity has been widely studied because of its diversity and complexity.Intestinal flora can promote the development of obesity through various mechanisms.This article reviews the relationship between intestinal flora and obesity and mechanisms of intestinal flora leading to obesity in recent years,and briefly reviews the progress of prevention and treatment of obesity based on intestinal flora as the intervention target.