摘要
In recent years,increasing attention has been paid to bioengineered bacteria as vectors for the treatment of allergic diseases.The methods for preparing bioengineered bacteria that can express exogenous genes are improving.Research has focused mainly on application of bioengineered bacteria expressing recombinant allergens,hypoallergenic derivatives of allergens,T-cell epitope derivatives,cytokines,or as mucosal adjuvants to enhance immunotherapy effects.This strategy offers new ideas for the treatment of allergic diseases.This review summarizes recent advances in use of live bioengineered bacteria in allergic diseases as well as the challenges of using microorganisms(or their components)in immunotherapy.
基金
supported by the Nanjing Incubation Program for National Clinical Research Center(No.2019060001)
the key project of Social Development in Jiangsu Province(No.BE2020632)
National Natural Science Foundation of China(No.82073446)
Medicine and Health Technology Innovation Project of Chinese Academy of Medical Sciences(No.2016-I2M-1-005)。
