摘要
脑源性神经营养因子(BDNF)的两种形式--成熟型BDNF(mBDNF)和BDNF前体(proBDNF)与相应的受体结合可介导一系列的生物信号, 对神经元的增殖、存活和凋亡均起着重要作用。目前已有越来越多的研究关注proBDNF向mBDNF的不平衡转化在阿尔茨海默病(AD)、帕金森病(PD)等神经退行性疾病中的作用, 以及它们作为疾病的生物标记物和治疗靶点方面的潜能。本文现围绕近年来BDNF及proBDNF/mBDNF失平衡在上述神经退行性疾病中的作用及治疗应用研究进展进行综述, 以期为AD、PD等神经退行性疾病的发病机制、早期诊断及治疗研究提供新的视角和途径。
The two forms of brain-derived neurotrophic factor(BDNF),mature BDNF(mBDNF)and BDNF precursor(proBDNF),bind to corresponding receptors and mediate a series of biological signals,which play important roles in proliferation,survival and apoptosis.More and more studies have focused on the role of unbalanced transformation from proBDNF to mBDNF in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease,as well as their potential as biomarkers and treatment targets.This article reviews the mechanism and therapeutic application of BDNF and proBDNF/mBDNF imbalance in the above-mentioned neurodegenerative diseases to provide new perspective and approach for the pathogenesis,early diagnosis and treatment of neurodegenerative diseases such as AD and PD.
作者
刘凤
刘利民
巫晓宇
邢维昊
熊静
Liu Feng;Liu Limin;Wu Xiaoyu;Xing Weihao;Xiong Jing(Department of Neurology,Second Affiliated Hospital of Kunming Medical University,Kunming 650106,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2023年第3期295-300,共6页
Chinese Journal of Neuromedicine
基金
云南省卫计委医学学科带头人培养计划(D-2017028)
云南省科技厅基础研究计划-昆医联合专项(202201AY070001-131)
昆明医科大学研究生创新基金(2022S292)。
