补阳还五汤联合达格列净治疗早期糖尿病肾病临床研究

Clinical Study on Buyang Huanwu Decoction Combined with Dagliegin for Early Diabetic Kidney Disease

目的:观察补阳还五汤联合达格列净对早期糖尿病肾病(DKD)患者的血糖控制及尿微量白蛋白水平的影响。方法:选择78例早期DKD患者,按随机数字表法分为观察组和对照组各39例。对照组给予达格列净治疗,观察组在对照组基础上给予补阳还五汤治疗。比较2组治疗前后空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)、血肌酐(SCr)、胱抑素C (Cys C)水平以及尿微量白蛋白排泄率(UAER)的变化。结果:治疗前,2组FBG、P2hBG、HbA1c水平比较,差异无统计学意义(P>0.05)。治疗后,2组FBG、P2hBG、HbA1c水平较治疗前降低(P<0.05),且观察组FBG、P2hBG、HbA1c水平低于对照组(P<0.05)。治疗前,2组血清SCr、Cys C、UAER水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清Cys C、UAER水平较治疗前下降(P<0.05),且观察组血清Cys C、UAER水平低于对照组(P<0.05)。结论:补阳还五汤联合达格列净治疗早期DKD可有效控制患者的血糖水平,同时可以减少尿微量白蛋白、保护肾功能。

Objective: To observe the effect of the therapy of Buyang Huanwu Decoction combined with Dagliazine on blood glucose control and urinary microalbumin levels in patients with early diabetic kidney disease(DKD). Methods: A total of 78 patients with early DKD were randomly divided into the observation group and the control group according to random number table method,with 39 cases in each group. The control group was treated with Dagliazine,and the observation group was additionally treated with Buyang Huanwu Decoction based on the treatment of the control group. The changes in the levels of fasting blood glucose(FBG),postmortem 2h blood glucose(P2hBG),glycosylated hemoglobin(HbA1c),serum creatinine(SCr), cystatin C(Cys C) and urinary albumin excretion rates(UAER) were compared between the two groups before and after treatment. Results:Before treatment,there was no significant difference in the levels of FBG,P2hBG and HbA1c between the two groups(P>0.05). After treatment,the levels of FBG,P2hBG and HbA1c in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of FBG,P2hBG and HbA1c in the observation group were lower than those in the control group(P<0.05). Before treatment,there was no significant difference in the levels of serum SCr,Cys C and UAER between the two groups(P>0.05). After treatment,the levels of serum Cys C and UAER in the two groups were decreased when compared with those before treatment(P<0.05),and the serum Cys C and UAER levels in the observation group were lower than those in the control group(P<0.05). Conclusion:The therapy of Buyang Huanwu Decoction combined with Dagliegin can effectively control the blood glucose levels of patients with early DKD,and can reduce the urinary microalbumin and protect the kidney function.