杏贝止咳颗粒联合常规西药治疗社区获得性肺炎患儿临床研究

Clinical Study on Xingbei Zhike Granules Combined with Routine Western Medicine for Children with Community-Acquired Pneumonia

目的:观察杏贝止咳颗粒联合常规西药对社区获得性肺炎患儿免疫功能、肺功能的影响。方法:选择120例社区获得性肺炎患儿为研究对象,按随机数字表法分为研究组和对照组各60例。对照组给予常规西药治疗,研究组在对照组基础上给予杏贝止咳颗粒治疗,2组均连续治疗7 d。比较2组治疗前后粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素-3(IL-3)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、25-羟维生素D[25 (OH) D]、免疫球蛋白(Ig) M、IgA、维生素D、最大呼气压(PEmax)、最大吸气压(PImax)、峰流速(PEF)、最大呼气中段流量(MMF)水平,并评价2组临床疗效。结果:研究组总有效率为96.67%,高于对照组83.33%(P<0.05)。治疗后,2组GM-CSF、IL-6、TNF-α、IL-3水平较治疗前降低,IgM、IgA、25 (OH) D、维生素D水平较治疗前升高(P<0.05);研究组GM-CSF、IL-6、TNF-α、IL-3水平低于对照组,IgM、IgA、25 (OH) D、维生素D水平高于对照组(P<0.05)。治疗后,2组PImax、PEmax、MMF、PEF水平较治疗前升高(P<0.05),研究组PImax、PEmax、MMF、PEF水平高于对照组(P<0.05)。结论:杏贝止咳颗粒联合常规西药治疗社区获得性肺炎患儿,可抑制炎症反应,改善患儿免疫功能及肺功能,提升临床疗效。

Objective:To observe the effect of Xingbei Zhike Granules combined with western medicine on the immune function and the lung function of children with community-acquired pneumonia. Methods:A total of 120 children with community-acquired pneumonia were selected as the research subjects and divided into the study group and the control group according to the random number table method,with60 cases in each group. The control group was treated with routine western medicine,and the study group was additionally given Xingbei Zhike Granules based on the treatment of the control group. The two groups were treated for consecutive 7 days. Before and after treatment,the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF),interleukin-3(IL-3),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),25-hydroxyvitamin D [25(OH)D],immunoglobulin-M(IgM),immunoglobulin-A(IgA),vitamin D, maximal expiratory pressure(PEmax), maximal inspiratory pressure(PImax), peak expiratory flow(PEF),and maximum mid-expiratory flow(MMF) in the two groups were compared,as well as the clinical effect was evaluated. Results:The total effective rate was 96.67% in the study group,higher than that of83.3% in the control group(P<0.05). After treatment,the levels of GM-CSF,IL-6,TNF-α,and IL-3 in both groups were decreased when compared with those before treatment, and the levels of IgM,IgA, 25(OH)D and vitamin D were increased(P<0.05);the levels of GM-CSF,IL-6,TNF-α,and IL-3in the study group were lower than those in the control group,and the levels of IgM,IgA,25(OH)D and vitamin D were higher than those in the control group(P<0.05). After treatment, the levels of PImax,PEmax,MMF and PEF in the two groups were increased when compared with those before treatment(P<0.05),and the above four levels in the study group were higher than those in the control group(P<0.05).Conclusion:Xingbei Zhike Granules combined with routine western medicine for children with communityacquired pneumonia can inhibit the inflammatory responses, improve the immune function and the lung function of children,and increase the clinical effect.