泸州家庭居民幽门螺杆菌感染情况及相关危险因素分析

Analysis of Helicobacter pylori infection status and risk factors among family residents in Luzhou area

目的 为了了解泸州市居家居民HP感染情况及有关危险因素,为泸州市人群家庭HP感染防治提供一定策略及参考。方法 随机抽取泸州市市区203组家庭共510例人群,采用13C尿素呼气试验(UBT)来检测是否有HP感染,对调查人群的一般情况、生活中个人习惯和消化道相病史等相关问题展开问卷调查,然后对所得数据进行相关统计学分析,根据Hp感染情况提出相应的预防对策。结果 在510个研究人群中,有146例幽门螺旋杆菌阳性者,占总人数的28.63%,分布在105个家庭中,平均每户1.39例。全部调查对象中,家庭中无人感染占48.27%(98/203)、家庭中1人感染占34.98%(71/203)、家庭中2人感染占14.29%(29/203)、家庭中2例及以上感染占2.46%(5/203)。在所调查总体中,男性203例(39.80%),平均年龄(49.13±21.81)岁;女性307例(60.20%),平均年龄(51.30±16.70)岁;不同性别中,男性HP的阳性率比女性要高(P>0.05),其中男性占32.02%,女性占26.38%;对各年龄段泸州居民进行HP阳性率的统计学分析,结果显示年龄在45~65岁之间的居民HP阳性率高于其他年龄段(P<0.05)。同时,患有胃部基础疾病的人群HP阳性率高于健康人群(P<0.05)。多因素Logistic回归分析结果显示既往曾患有胃部基础疾病是泸州市家庭居民幽门螺杆菌感染的危险因素。结论 泸州市幽门螺杆菌感染特点具有一定的家庭聚集性,且幽门螺杆菌感染随年龄呈现先升后降趋势,患有胃部疾病为HP感染的危险因素,应加大对HP感染的宣教,抗Hp治疗的同时应积极治疗胃部基础疾病,鼓励家庭成员同检同治,避免聚集性感染。

Objective To investigate the HP infection situation and related risk factors of household residents in Luzhou City,and to provide some effective strategies and references for the prevention and treatment of household HP infection in Luzhou City.Methods A total of 510 cases were randomly selected from 203 groups of families in Luzhou City.13C urea breath test(UBT)was used to detect HP infection.Questionnaire survey was conducted on the general situation,personal habits in daily life and history of gastrointestinal disease of the population,and then statistical analysis was conducted on the obtained data.According to the situation of Hp infection,the corresponding preventive measures are put forward.Results Among the 510 study population,there were 146 H.pylori positive cases,accounting for 28.63%of the total number,distributed among 105 households,with an average of 1.39 cases per household.Of the total surveyed population,no one in the household was infected in 48.27%(98/203),1 person in the household was infected in 34.98%(71/203),2 persons in the household were infected in 14.29%(29/203),and 2 cases and more in the household were infected in 2.46%(5/203).Among the overall surveyed,203 cases(39.80%)were males with a mean age of(49.13±21.81)years and 307 cases(60.20%)were females with a mean age of(51.30±16.70)years;among the different genders,the positive rate of H.pylori was higher in males than in females(P>0.05),Among them,32.02%were males and 26.38%were females;statistical analysis of the HP positivity rate among residents in each age group showed that the HP positivity rate among residents aged 45-65 years was higher than other age groups(P<0.05).Also,the rate of H.pylori positivity was higher in those with gastric diseases(P<0.05).Multifactorial Logistic regression analysis showed that previous gastric diseases were risk factors for H.pylori infection.Conclusion There is family aggregation of H.pylori infection in Luzhou area,and H.pylori infection shows a trend of increasing and then decreasing with age,and having gastric disease is a risk factor for HP infection,so we should increase the education on HP infection,actively treat the underlying gastric disease along with anti-Hp treatment,and encourage family members to be examined and treated together to avoid aggregation of infection.