胃食管反流病患者服药依从性现状及影响因素分析

To analyze the current status and influencing factors of medication compliance in patients with gastroesophageal reflux disease

目的 探索胃食管反流病(GERD)患者服药依从性现状及影响因素。方法 对2020年10月至2021年6月就诊于广州市南方医科大学南方医院消化内科的200例GERD患者进行问卷调查,包括一般资料问卷、药物依从性评估与鉴别量表、社会支持量表。比较GERD患者药物依从性评估与鉴别量表评分在不同人口学特征、病程、保险、社会支持等方面的差异;采用多元线性回归分析GERD患者药物依从性评估与鉴别量表总分的独立影响因素。结果 200例GERD患者的药物依从性评估与鉴别量表平均分为(27.78±9.21)分。年龄、文化程度、病程、保险、居住地、社会支持等是GERD患者药物依从性评估与鉴别量表总分的影响因素(P均<0.05)。多元线性回归显示,社会支持是GERD患者药物依从性评估与鉴别量表总分的独立保护因素;文化程度初中及以下、居住在农村、自费、病程12~24月和≥36月、年龄≤60岁是独立危险因素。结论 社会支持度低、文化程度初中及以下、居住在农村、自费、病程12~24月和≥36月、年龄≤60岁是GERD患者服药依从性差的危险因素。医务人员应对存在以上特征的GERD患者加强服药依从性的教育,并鼓励家属参与到患者的治疗中。

Objective To explore the status quo and influencing factors of medication compliance in patients with gastroesophageal reflux.Methods From October 2020 to June 2021,200 patients with gastroesophageal reflux disease admitted to the Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou were investigated by questionnaires,including general data questionnaire,the medication adherence estimation and differentiation scale,and social support rating scale.To compare the differences of the medication adherence estimation and differentiation scale scores in different demographic characteristics,course of disease,insurance,social support.Multiple Logistic regression analysis was used to analyze the independent influencing factors of drug compliance assessment and total score of the medication adherence estimation and differentiation scale in patients with gastroesophageal reflux disease.Results The average score of the medication adherence estimation and differentiation scale in 200 patients with gastroesophageal reflux disease was(27.78±9.21).Age,education,course of disease,insurance,residence and social support were the factors affecting the evaluation of medication compliance and the total score of the medication adherence estimation and differentiation scale in patients with gastroesophageal reflux disease(all P<0.05).By multiple Logistic regression analysis,showed that social support was an independent protective factor for the assessment of medication compliance and the total score of the medication adherence estimation and differentiation scale in patients with gastroesophageal reflux disease.Education level of junior high school or below,living in rural areas,self-payment,disease duration of 12~24 months and≥36 months,age≤60 years old were independent risk factors.Conclusion Low social support,education level of junior high or below,living in rural areas,self-payment,duration of disease 12-24 months and≥36 months,age≤60 years old are risk factors for poor medication compliance in patients with gastroesophageal reflux disease.Medical staff should strengthen the education of medication compliance for patients with gastroesophageal reflux disease with the above conditions,and encourage family members to participate in the treatment of patients.