类风湿关节炎疾病活动度评估方法及分析

Rheumatoid Arthritis Disease Activity Assessment Methods and Analysis

进行疾病活动度评估对于指导类风湿关节炎(rheumatoid arthritis,RA)的治疗及改善患者预后具有重要意义,目前已知的多种疾病活动度评估工具各有优缺点,在临床应用中尚存在争议。随着科学技术的发展,光学生物传感器被应用于医学研究,其中拉曼光谱(Raman spectra,RS)可以进行多种生物标记物的检测,但目前尚无应用于类风湿关节炎的相关研究。本文就临床常用的疾病活动度评估方式展开综述,并探讨拉曼光谱在类风湿关节炎疾病活动度评估中应用的可行性。

Disease activity assessment is of great significance for guiding the treatment of rheumatoid arthritis(RA)and improving the prognosis of patients.Currently,many known disease activity assessment tools have their advantages and disadvantages,which are still controversial in clinical application.With the development of science and technology,optical biosensors are applied in medical research,among which Raman spectra(RS)can detect a variety of biomarkers,but it has not been applied in the related research of rheumatoid arthritis.This paper reviews the commonly used clinical methods of disease activity assessment,and discusses the feasibility of application of Raman spectroscopy in the disease activity assessment of rheumatoid arthritis.