豨莶草提取物及其活性成分治疗关节炎的研究进展

Progress in Therapeutic Mechanism of Siegesbeckiae Herba Extract and Active Components for the Treatment of Arthritis

豨莶草性寒,味辛、苦,具有祛风湿、利关节的功效,是治疗风湿痹证、骨节疼痛的传统中药之一,也是现代中医临床治疗关节炎的常用中药。近年来的临床研究与基础研究表明,豨莶草提取物及其活性成分主要通过保护软骨细胞、维持破骨细胞与成骨细胞的动态平衡、抑制促炎因子的释放等作用阻止骨性关节炎的发展;豨莶草提取物及其活性成分治疗痛风性关节炎的作用机制主要与减少滑膜炎症与尿酸形成、抗氧化应激反应、调节促炎因子水平等有关。综述豨莶草治疗骨性关节炎和痛风性关节炎两种关节炎的研究进展,可为关节炎发病机制的深入研究和治疗关节炎新药的研发提供参考。

Siegesbeckiae Herba is cold in nature, and is pungent and bitter in taste, with the actions of dispelling wind-damp and activating joints. It is one of the traditional Chinese medicines for the treatment of winddamp arthralgia and pain in the bone and joints,and is also a commonly-used Chinese medicine for the treatment of arthritis in modern Chinese medicine clinical practice. The clinical study and fundamental research in recent years showed that the extract of Siegesbeckiae Herba and its active ingredients are effective on arresting the development of osteoarthritis by protecting chondrocytes, maintaining the dynamic balance between osteoclasts and osteoblasts, and inhibiting the release of pro-inflammatory factors. The therapeutic mechanism of Siegesbeckiae Herba extract and its active ingredients for the treatment of gouty arthritis is mainly related to the reduction of synovial inflammation and uric acid formation, counteraction of the oxidative stress response and regulation of pro-inflammatory factor levels. The review of the research progress in the treatment of osteoarthritis and gouty arthritis with Siegesbeckiae Herba will provide a reference for the in-depth research of the pathogenic mechanism of arthritis and the development of anti-arthritis new drugs.