肠道菌群代谢产物与间充质干细胞相互作用的研究进展

Research progress in the interaction between intestinal flora metabolites and mesenchymal stem cells

间充质干细胞(MSCs)具有增殖分化和调节免疫的作用,在治疗多种自身免疫性疾病的过程中表现出良好的效果,应用前景广阔。多项研究显示肠道菌群的代谢产物可以影响MSCs的功能,而MSCs亦可对肠道菌群代谢产物的生成进行调控。本文就一些常见的肠道菌群代谢产物(短链脂肪酸、氧化三甲胺、胆汁酸和色氨酸代谢物)与MSCs的相互作用进行归纳总结,并探讨基于肠道菌群代谢产物靶向调控MSCs的可行策略,为包括自身免疫性疾病在内的多种疾病的研究提供新思路。

Due to the function of proliferation,differentiation and immune regulation,mesenchymal stem cells(MSCs)have broad application prospects and currently show promising results in treating various autoimmune diseases.Related research shows that the metabolites of intestinal flora affect the function of MSCs,and MSCs also regulate the production of intestinal flora metabolites.Based on previous studies,this article reviews the interaction between some common intestinal flora metabolites(short-chain fatty acids,trimethylamine oxide,bile acids,and tryptophan metabolites)and MSCs.In addition,some feasible strategies for targeted regulation of MSCs based on intestinal flora metabolites are discussed,which can provide new ideas for studying various diseases,including autoimmune diseases.