间充质干细胞与巨噬细胞相互作用机制的研究进展

Research progress in the interaction mechanism between mesenchymalstem cells and macrophages

间充质干细胞(MSCs)主要通过旁分泌作用于免疫细胞而参与组织修复与重塑。巨噬细胞具有吞噬杀伤和免疫调节功能,与组织细胞协调应对病理和生理应激。在炎症反应中,MSCs能借助多种方式使促炎的M1型巨噬细胞向抗炎的M2型巨噬细胞转化,调控炎症因子、抑制炎症反应和减少组织细胞损伤;同时,炎症微环境中的巨噬细胞释放多种因子也对MSCs的生物学功能产生影响。本文综述了MSCs和巨噬细胞相互作用机制及双方信息交换的研究进展,涉及细胞因子分泌、旁分泌和细胞间直接接触等方式,为优化MSCs生物学功能、修复炎症性组织损伤提供策略和方案。

Mesenchymal stem cells(MSCs)mainly act on immune cells through the paracrine and participate in tissue repair and remodelling.Macrophages have the functions of phagocytosis and immune regulation and coordinate with many types of cells to cope with pathophysiological stress.In the inflammatory response,MSCs transform pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages in a variety of ways,regulate inflammatory factors,inhibit inflammatory responses and reduce tissue cell damage;At the same time,the release of multiple factors by macrophages in the inflammatory microenvironment also affects the biological function of MSCs.This review summarises the interaction mechanism between MSCs and macrophages,and the latest research progress in their information exchange,involving cytokine secretion,paracrine and intercellular direct contact.It will provide the strategy and scheme for optimizing MSCs'function to repair inflammatory tissue damage.