竞争内源性RNA在胰腺癌研究中的进展

Advances in competing endogenous Rnas in pancreatic cancer

胰腺癌是恶性程度极高的消化系统肿瘤,胰腺导管腺癌(PDAC)是胰腺癌中最常见的一种病理类型。目前诊断胰腺癌的生物学指标仍有限,且特异性有待进一步提升。胰腺癌普遍发病隐匿,进展快,机制不确定。近年来已出现了大量有关胰腺癌生物学功能相关的分子生物学研究,竞争性内源RNA(ceRNA)假说是研究较多的假说之一。有研究表明,长链非编码RNA(lncRNA)、环状RNA(circRNA)、假基因可作为ceRNA参与ceRNA网络构建,通过相应的途径影响胰腺癌细胞的生物学功能。近年来大量的研究发现ceRNA在胰腺癌的产生、发展以及对化疗药物的耐药性等方面中发挥重要作用。本文旨在对近年来有关ceRNA在胰腺癌细胞生物学功能的影响作出系统性的总结和分析,并对未来的相关研究提出参考方向。

Pancreatic cancer is a highly malignant digestive system tumor,and pancreatic ductal adenocarcinoma(PDAC)is the most common pathological type of pancreatic cancer.At present,the biological indicators for the diagnosis of pancreatic cancer are still limited,and the specificity needs to be further improved.Pancreatic cancer is a common disease with occult onset,rapid progression and uncertain mechanism.In recent years,there have been a lot of molecular studies on the biological function of pancreatic.cancer,and the competitive endogenous RNA(ceRNA)hypothesis is one of the most studied hypotheses.Studies have shown that long non-coding Rnas(lncrnas),circrnas(circrnas)and pseudogenes can be used as CERnas to participate in the construction of ceRNA networks and affect the biological function of pancreatic cancer cells through corresponding pathways.In recent years,a large number of studies have found that ceRNA plays an important role in the generation,development and resistance to chemotherapy drugs of pancreatic cancer.The purpose of this paper is to systematically summarize and analyze the effects of ceRNA on biological function of pancreatic cancer cells in recent years,and to provide reference for future research.