摘要
胰腺癌是恶性程度高的消化系统肿瘤,随着非编码RNA在胰腺癌中的研究不断深入,发现非编码RNA具有作为诊断胰腺癌生物标志物和治疗靶点的重要潜能。外周血非编码RNA的检测更是因简便、非侵入性等优势而深受广大研究者的青睐。通过搜集近些年来外周血非编码RNA与胰腺癌的相关研究,本文将从微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)三方面对外周血非编码RNA在胰腺癌诊疗中的研究进展作一综述。
Pancreatic cancer is a digestive system tumor with a high degree of malignancy.With the deepening of research on non-coding RNA in pancreatic cancer,it has been found that non-coding RNA has important potential as biomarkers and therapeutic targets in the diagnosis of pancreatic cancer.The detection of peripheral blood non-coding RNA is favored by the majority of researchers because of its simplicity and non-invasive advantages.By collecting relevant studies on peripheral blood non-coding Rnas and pancreatic cancer in recent years,this paper reviews the research progress of peripheral blood non-coding Rnas in the diagnosis and treatment of pancreatic cancer from the perspectives of micrornas(mirnas),long-chain non-coding Rnas(lncrnas)and circrnas.
作者
李泽乾
郝少龙
张博
纪凯伦
韩威
Li Zeqian;Hao Shaoong;Zhang Bo;Ji Kailun;Han Wei(Department of General Surgery,Beijing Luhe Hospital,Capital Medical University,Beijing 101100,China)
出处
《中华普外科手术学杂志(电子版)》
2023年第2期217-220,共4页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
基金
首都卫生发展科研专项(首发2022-2-7081)
北京市通州区科技计划项目(KJ2022CX016)。
关键词
胰腺肿瘤
非编码RNA
外周血
生物标记
肿瘤
Pancreatic Neoplasms
Non-Coding RNA
Peripheral Blood
Biomarkers,Tumor