外周血非编码RNA在胰腺癌中研究进展

Research progress of peripheral blood non-coding RNA in pancreatic cancer

胰腺癌是恶性程度高的消化系统肿瘤,随着非编码RNA在胰腺癌中的研究不断深入,发现非编码RNA具有作为诊断胰腺癌生物标志物和治疗靶点的重要潜能。外周血非编码RNA的检测更是因简便、非侵入性等优势而深受广大研究者的青睐。通过搜集近些年来外周血非编码RNA与胰腺癌的相关研究,本文将从微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)三方面对外周血非编码RNA在胰腺癌诊疗中的研究进展作一综述。

Pancreatic cancer is a digestive system tumor with a high degree of malignancy.With the deepening of research on non-coding RNA in pancreatic cancer,it has been found that non-coding RNA has important potential as biomarkers and therapeutic targets in the diagnosis of pancreatic cancer.The detection of peripheral blood non-coding RNA is favored by the majority of researchers because of its simplicity and non-invasive advantages.By collecting relevant studies on peripheral blood non-coding Rnas and pancreatic cancer in recent years,this paper reviews the research progress of peripheral blood non-coding Rnas in the diagnosis and treatment of pancreatic cancer from the perspectives of micrornas(mirnas),long-chain non-coding Rnas(lncrnas)and circrnas.