铜催化不饱和化合物硅加成反应的研究进展

Recent Advances in Copper-Catalyzed Silyl Addition of Unsaturated Compounds

有机硅化合物不仅是十分有用的功能分子,而且是非常重要的有机合成中间体,在一定条件下通过适当的化学方法,可以转化为很多其它有用的功能性化合物.到目前为止,已经陆续发展了各种过渡金属参与的催化方法来制备有机硅化合物,其中铜催化不饱和化合物的硅加成反应是一种重要的合成有机硅化合物的方法.从不饱和化合物的种类出发,主要涉及α,β-不饱和化合物、亚胺、Morita-Baylis-Hillman(MBH)醇类化合物、对苯醌甲基化合物、α,β-不饱和炔羰化合物以及α,β-不饱和砜类化合物,综述了近几年在铜催化作用下这些不饱和化合物通过硅加成反应合成有机硅化合物的最新研究进展,有利于加深对铜催化硅加成反应的理解.

Organosilicons are not only very useful functional molecules,but also important organic synthetic intermediates.It could be easily transformed into many other useful functional compounds under various conditions.So far,a lot of transition metal-catalyzed methods have been developed to prepare organosilicon compounds.Among them,copper-catalyzed silyl addition reactions to unsaturated compounds are extremely important for the synthesis of organosilicon compounds.Herein,the recent research progress in the synthesis of organosilicons by copper-catalyzed silyl addition of silyl reagents to diverse unsaturated compounds such asα,β-unsaturated carbonyl compounds,imines,Morita-Baylis-Hillman(MBH)alcohols,p-quinone methides,α,β-unsaturated alkyne carbonyl compounds andα,β-unsaturated sulfones is summarized.It will largely promote the development of such copper-catalyzed silyl addition reactions.