沙眼衣原体的毒力因子研究进展

Research progress on virulence factors of Chlamydia trachomatis

沙眼衣原体(Chlamydia trachomatis,Ct)是一种常见的专性细胞内寄生微生物,他能够引起女性宫颈炎、输卵管炎、盆腔炎、子宫内膜炎等多种疾病,是最为常见的性传播病原体之一,迄今也没有特异性Ct疫苗可以预防其传播。目前关于Ct的致病机制还没有完全研究明白,但由于分子生物学,生物信息学,生物物理学的迅速发展,现在已经克隆并验证了包括热休克蛋白、主要外膜蛋白、衣原体分泌蛋白、质粒蛋白和一些新发现的可能的毒力蛋白。本研究对其毒力因子的进展进行研究,为预防和控制Ct所致的疾病提供参考。

Chlamydia trachomatis(Ct)is a common obligate intracellular parasitic microorganism.It can cause female cervicitis,salpingitis,pelvic inflammation,endometritis and other diseases,and is also one of the most common sexually transmitted pathogens.So far,there is no specific Ct vaccine to prevent its transmission.At present,the pathogenic mechanism of Ct has not been fully understood,but it has been cloned and verified,including heat shock protein,main outer membrane protein,chlamydial secretory protein,plasmid protein and some newly-discovered possible virulence proteins due to the rapid development of molecular biology,bioinformatics and biophysics.This study introduces the research progress on these virulence factors so as to provide references for prevention and control of Ct-induced diseases.