硫酸镁联合硝苯地平治疗妊娠高血压综合征的临床效果

Clinical effect of Magnesium Sulfate combined with Nifedipine in the treatment of pregnancy-induced hypertension syndrome

目的探讨硫酸镁联合硝苯地平治疗妊娠高血压综合征的临床效果。方法选取2019年6月至2022年1月济宁市兖州区人民医院收治的80例妊娠高血压综合征患者,按照随机数字表法分为对照组与实验组,每组各40例。对照组予以硫酸镁治疗,实验组在对照组基础上予以硝苯地平治疗。比较两组治疗效果、症状体征、尿蛋白指标、红细胞比容、脐动脉阻力指数和血黏度。结果实验组总有效率高于对照组(P<0.05)。实验组尿蛋白阳性率、水肿率、舒张压与收缩压均低于对照组(P<0.05)。治疗后,两组尿钙黏蛋白、尿激肽原1和24 h尿蛋白均低于治疗前,且实验组低于对照组(P<0.05)。治疗后,两组红细胞比容、脐动脉阻力指数和血黏度均低于治疗前,且实验组低于对照组(P<0.05)。结论硫酸镁联合硝苯地平治疗妊娠高血压综合征疗效显著,可改善患者症状体征、尿蛋白指标,降低血黏度,值得推广应用。

Objective To investigate the clinical effect of Magnesium Sulfate combined with Nifedipine in the treatment of pregnancy-induced hypertension syndrome.Methods A total of 80 patients with pregnancy-induced hypertension syndrome admitted to Jining Yanzhou District People’s Hospital from June 2019 to January 2022 were selected and divided into the control group and the experimental group according to the random number table method,with 40 cases in each group.The control group was treated with Magnesium Sulfate,and the experimental group was treated with Nifedipine on the basis of the control group.The therapeutic effect,symptoms and signs,urinary protein index,hematocrit value,umbilical artery resistance index and blood viscosity were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group(P<0.05).Urine protein positive rate,edema rate,diastolic blood pressure and systolic blood pressure in the experimental group were lower than those in the control group(P<0.05).After treatment,urinary cadherin,urokinin 1 and 24 h urinary protein in both groups were lower than those before treatment,and those in the experimental group were lower than those in the control group(P<0.05).After treatment,the hematocrit value,umbilical artery resistance index and blood viscosity in both groups were lower than those before treatment,and those in the experimental group were lower than those in the control group(P<0.05).Conclusion Magnesium Sulfate combined with Nifedipine has significant curative effect in the treatment of pregnancy-induced hypertension syndrome,which can improve symptoms,signs and urinary protein indexes,and reduce blood viscosity.It is worth popularizing and applying.