微重力对细胞衰老影响的研究进展

Research Progress of the Effect of Microgravity on Cellular Senescence

微重力是太空环境的典型特征。大量的太空飞行以及地基模拟实验显示,在微重力/模拟微重力效应刺激下细胞展现出细胞增殖减少和细胞周期停滞等衰老的典型生物学特征,但微重力/模拟微重力效应影响细胞衰老的分子机制尚不十分清楚。加深对微重力环境影响细胞衰老机制的认识有助于探索太空微重力环境下的抗衰老策略和靶向干预手段。近年来,国内外学者在微重力/模拟微重力效应对细胞衰老的影响和相关机制方面开展了较多的研究探索,本文就相关研究进展进行综述。

Microgravity is a typical feature of the space.A large number of space flights and foundation simulation experiments have shown that cells show typical biological characteristics of aging,such as reduced cell proliferation and cell cycle arrest under microgravity or simulated microgravity.However,the molecular mechanism by which microgravity or simulated microgravity affects cellular senescence is not well understood.Understanding the mechanism controlling cellular senescence induced by microgravity environment is helpful for exploring anti-aging strategies and targeted interventions in space.In recent years,domestic and foreign scholars have carried out a number of researches and explorations on the effect of microgravity and simulated microgravity on cellular senescence as well as the related mechanisms.In this review,the latest research progress of this filed was summarized.