摘要
抑郁症以情绪低落、兴趣减退和快感缺失为主要临床特点。童年创伤作为重要的社会环境因素之一,增加了日后罹患抑郁症的风险。研究童年创伤与抑郁症发生的关系及机制对抑郁症的防治至关重要。炎性反应紊乱可能是童年创伤导致抑郁症的生物学机制之一,现就童年创伤经历与抑郁症发病之间的炎症机制进行综述。
Depressive disorder is a chronic mental disorder characterized by low mood,decreased interest and anhedonia.As one of the important social environmental factors,childhood traumatic experience increases the risk of depression in the future.It is important to study the relationship and mechanism between childhood traumatic experience and depression for the prevention and treatment of depression.Inflammatory reaction disorder may be one of the biological mechanisms of childhood traumatic experience leading to depression.This article reviews the inflammatory mechanism between childhood trauma and depression.
作者
封俊杰
丁莉莉
李天舒
尤红
段蕾梅
金圭星
王小曼
Feng Junjie;Ding Lili;Li Tianshu;You Hong;Duan Leimei;Jin Guixing;Wang Xiaoman(Department of Psychology,Handan Central Hospital,Handan 056001,China;Handan Psychiatric Hospital,Handan 056001,China;Department of Psychiatry,the First Hospital of Hebei Medical University,Shijiazhang 050301,China;Mental Health Center,Fengfeng General Hospital of North China Medical and Health Group,Handan 056001,China)
出处
《神经疾病与精神卫生》
2023年第2期145-148,共4页
Journal of Neuroscience and Mental Health
基金
河北省卫生健康委科研基金(20201168)
河北省邯郸市科技局基金项目(19422083009-5)。
关键词
抑郁症
童年创伤
炎症
细胞因子
综述
Depressive disorder
Childhood trauma
Inflammation
Cytokines
Review
