多模式运动对轻度认知功能障碍老年人认知功能、神经营养因子及全脑体积的影响

Effects of Multimodal Exercise on Cognitive Function,Neurotrophic Factors,and Whole Brain Volume in MCI Elderly

目的:探索多模式运动对轻度认知功能障碍(mild cognitive impairment,MCI)老年人认知功能、神经营养因子(neurotrophic factors,NFs)及全脑体积的影响。方法:26名MCI老年人参与实验,随机分为对照组[n=14,年龄(74.77±6.04)岁]与运动组[n=12,年龄(73.83±7.51)岁],运动组进行20周多模式运动干预(60 min/次,3次/周)。评估干预前后认知功能、全脑体积及外周血清NFs水平。配对比较干预前后各类数据变化,并对认知功能变化与NFs、全脑体积变化关系进行相关分析。结果:运动干预后MCI老年人整体认知功能、注意力、言语流畅性显著提高(P<0.05),逻辑记忆与执行功能无明显变化(P>0.05);外周血清NFs水平升高、脑灰质体积增大、脑脊液体积缩小、脑组织分数占比提高(P<0.05);注意力与言语流畅性变化与脑灰质体积、脑组织分数,外周血清NFs水平的变化相关。结论:多模式运动干预可改善MCI老年人整体认知功能、注意力与言语流畅性,提高血清NFs水平,引起脑灰质体积增大,脑脊液体积缩小,脑组织分数占比提高;NFs在运动引起MCI老年人认知功能与脑结构改善上可能发挥中介作用。

Objective:To explore the effects of multimodal exercise on cognitive function,neurotrophic factors(NFs),and whole brain volume in the elderly with mild cognitive impairment(MCI).Methods:Twenty-six MCI elderly people participate in the experiment and are randomized to the control group[n=14,age(74.77±6.04)]and the exercise group[n=12,age(73.83±7.51)].The exercise group receive a 20-week multimodal exercise intervention(60 min/time,3 times/week).Cognitive function,whole brain volume,and peripheral serum NFs level are evaluated before and after the intervention.All kinds of data changes before and after the intervention are compared in pairs,and the correlation between the changes in cognitive function and the changes in NFs and whole brain volume is analyzed.Results:After exercise intervention,the overall cognitive function,attention,and verbal fluency of the MCI elderly are significantly improved(P<0.05),while logical memory and executive function have no significant change(P>0.05);the level of peripheral serum NFs increases,the volume of gray matter increases,the volume of cerebrospinal fluid decreases,and the proportion of brain tissue fraction increases(P<0.05);changes of attention and verbal fluency are related to changes of gray matter volume,brain tissue fraction,and peripheral serum NFs level.Conclusions:Multimodal exercise intervention improves the overall cognitive function,attention,and verbal fluency in the MCI elderly,increases the serum NFs level,increases the volume of gray matter,decreases the volume of cerebrospinal fluid,and increases the proportion of brain tissue fraction;NFs may play a mediating role in the improvement of cognitive function and brain structure in the MCI elderly induced by exercise.