铁蓄积在破骨细胞增殖分化作用中的研究进展

Research progress on iron accumulation in the proliferation and differentiation of osteoclasts

破骨细胞是人体唯一具有骨吸收功能的细胞,在骨修复重建过程中发挥着不可代替的作用。近年研究发现铁蓄积与破骨细胞增殖分化异常密切相关,铁蓄积通过产生大量活性氧,激活下游丝裂原活化蛋白激酶与核因子-κB通路,诱导破骨细胞的增殖分化,从而引起骨量丢失,削弱骨骼强度。本文就铁蓄积调控破骨细胞增殖分化的相关机制进行综述。

Osteoclasts are the only cells in the human body with bone resorption function and play an irreplaceable role in the process of bone repair and reconstruction.In recent years,it has been found that iron accumulation is closely related to the proliferation and differentiation of osteoclasts,iron accumulation activates the downstream mitogen-activated protein kinase and nuclear factor-κB pathway by generating a large amount of reactive oxygen species,inducing the proliferation and differentiation of osteoclasts,thereby causing bone loss and weakening bone strength.In this paper,the relevant mechanisms of iron accumulation regulating the proliferation and differentiation of osteoclasts are reviewed.