针灸治疗膝骨关节炎的作用机制研究

Effect of acupuncture and moxibustion on knee osteoarthritis based on gut-joint axis

针灸治疗膝骨性关节炎虽可抑制炎症反应和延缓关节软骨退变,但其作用机制仍在探究中。现以肠道微生物介导的肠-关节轴为切入点,从经络脏腑理论分析,针灸可通过以下途径发挥治疗膝骨性关节炎的作用:调理气机升降;调节胃肠道动力,促进机体调节;调控肠道菌群平衡,使其恢复稳态;稳固肠黏膜机械屏障,维持肠道通透性。本文基于肠-关节轴理论,阐明针灸-肠道菌群-炎症反应之间具体作用机制,针灸可通过多通路、多靶点、双向性治疗膝骨关节炎,以期为针灸治疗膝骨性关节炎提供理论依据,为后期临床推广应用。

Although acupuncture can slow down the inflammatory process and postpone articular cartilage degradation in the treatment of knee osteoarthritis,the exact mechanism of action is still being investigated.Acupuncture can help treat osteoarthritis of the knee by regulating the elevation of qi,controlling the dynamics of the gastrointestinal tract and promoting body regulation,regulating the balance of intestinal flora and restoring it to homeostasis,stabilizing the mechanical biceps,and targeting the intestinal microbial-mediated intestine-joint axis.With the aim of providing a theoretical foundation for the treatment of osteoarthritis of the knee with acupuncture,which is deserving of clinical promotion and application,it is argued that acupuncture can treat osteoarthritis of the knee through multiple pathways,multiple targets,and bi-directionality.This relationship between acupuncture,gut flora,and inflammatory response is then clarified.