补肾活血中药联合西药治疗慢性再生障碍性贫血疗效Meta分析

Tonifying kidney and activating blood circulation combined with western medicine in treatment of chronic aplastic anemia:a meta-analysis

目的 通过Meta分析系统评价补肾活血法治疗慢性再生障碍性贫血(AA)的疗效。方法 以“补肾活血法”和“再生障碍性贫血”为关键词,时间范围为建库至2022年4月,通过计算机检索PubMed数据库、知网(CNKI)、万方(Wangfang)、中国生物医学文献数据库(CBM)、维普(VIP)中关于补肾生血法治疗慢性AA疗效的文献。提取文献的相关原始数据,通过Meta分析补肾活血法治疗慢性AA的有效率。结果 共纳入文献13篇,通过特定的效应模型处理,OR=1.30,95%CI:1.21~1.40。结果显示,补肾活血法辅助西医疗法治疗慢性AA疗效优于其他单纯西医疗法(Z=7.05,P<0.05)。结论 补肾活血法方剂结合西药的协同治疗慢性AA明显优于单一的西药疗法。

Objective To systematically evaluate the therapeutic effect of tonifying kidney and activating blood circulation in the treatment of chronic aplastic anemia(CAA)using meta-analysis system.Methods Taking“kidney tonifying and blood activating method”and“aplastic anemia”as key words,the relevant literature of supplementing the kidney and invigorating the blood circulation in the treatment of CAA were retrieved in the PubMed,CNKI,Wangfang,CBM and VIP databases.The retrieval time was from the establishment of the databases to April 2022.After extracting the relevant original data,the effective rate of tonifying the kidney and activating blood circulation in the treatment of CAA was analyzed through meta-analysis.Results A total of 13 articles were included,and the combined OR was 1.30(95%CI:1.21-1.40)for combined effects by specific effect model.Meta analysis suggested that the therapeutic effect of tonifying the kidney and activating blood circulation with Western medicine for CAA was superior to that of other western medicine alone(Z=7.05,P<0.05).Conclusion Tonifying kidney and activating blood circulation with western medicine has a better effect than routine western medicine therapy alone for CAA.