血清尿酸/高密度脂蛋白胆固醇比值与桥本甲状腺炎的相关性

Correlation between serum uric acid to high-density lipoprotein cholesterol ratio and Hashimoto's thyroiditis

目的 比较桥本甲状腺炎患者的尿酸与高密度脂蛋白比值(UHR)与健康人的差异。方法 选择2021年6月到至9月北部战区总医院内科门诊经病史、体格检查、血清甲状腺自身抗体水平升高及声像图特征确诊为桥本甲状腺炎的患者63例进行回顾性研究。年龄和性别匹配的健康志愿者106例被纳入为对照。比较桥本甲状腺炎患者和对照受试者的UHR和其他实验室参数。结果 桥本甲状腺炎组的UHR为0.41±0.13,而对照组的UHR为0.30±0.07,桥本甲状腺炎组的UHR显著高于对照组的UHR(P<0.01)。UHR与促甲状腺激素(TSH)呈显著正相关(r=0.15,P=0.049),与游离T4(FT4)呈负相关(r=-0.38,P<0.01)。UHR>37.5%的灵敏度和特异度分别为78%和80%(AUC=0.79,95%CI:0.707~0.868,P<0.01)。结论 UHR是桥本甲状腺炎可靠和有用的标志物。UHR可能有助于建立桥本甲状腺炎的诊断。

Objective To compare the differences in serum uric acid(UA)to high-density lipoprotein cholesterol(HDL-C)ratio(UHR)and other laboratory parameters between Hashimoto's thyroiditis(HT)patients and healthy people.Methods A retrospective study was performed on 63 patients with HT confirmed by medical history,physical examination,elevated thyroid autoantibodies in serum and characteristic sonographic findings in the General Hospital of Northern Theater Command from June to September 2021(HT group).The age-and gender-matched 106 healthy volunteers were enrolled as the control group.UHR and other laboratory parameters were compared between two groups.Results UHR in HT group was significantly higher than that in control group(0.41±0.13 vs 0.30±0.07,P<0.01).UHR was positively correlated with thyroid stimulating hormone(TSH)level(r=0.15,P=0.049)and was negatively correlated with free T4(FT4)level(r=-0.38,P<0.01).UHR greater than 37.5%had 78%sensitivity and 80%specify in predicting Hashimoto's thyroiditis(AUC=0.79,95%CI:0.707-0.868,P<0.01).Conclusion UHR is a reliable and useful marker of HT and may be helpful to establish the diagnosis of Hashimoto's thyroiditis.