摘要
To the Editor:In breast cancer,it is the metastasis that makes a clear distinction between life and death.^([1,2])However,effective treatment targeted against metastasis remains an unmet clinical need.^([2,3])Accumulating evidence suggests that an essential step in metastasis is tumor cell acquisition of motility.^([2])Furthermore,epithelial-mesenchymal transition(EMT)initiates the early steps of tumor cell spread by endowing them with greater motility and invasiveness.