黑色素瘤缺乏因子-2炎症小体在感染中的作用机制研究进展

Research progress on the mechanism of AIM2 inflammasome in infection

黑色素瘤缺乏因子-2(Absent in melanoma-2,AIM2)是存在于细胞质中的模式识别受体,它能够识别内源性或外源性的双链DNA并组装一种称为炎症小体的蛋白聚合物,介导白介素-1β(Interleukin-1β,IL-1β)、白介素-18(Interleukin-18,IL-18)的成熟与释放,促使细胞发生炎症性的程序性死亡—细胞焦亡。AIM2对外源性DNA的识别有助于宿主抵抗各类病原微生物的感染,例如各种细菌、病毒、真菌以及寄生虫。本文就AIM2炎症小体在感染中的作用机制研究进展进行综述。

Absent in melanoma-2(AIM-2)is a cytosolic innate pattern recognition receptor which binds to endogenous or exogenous double-stranded DNA and trigger the assembly of a multiprotein complex called the inflammasome.The inflammasome leads to the maturation and secretion of the interleukin-1β(IL-1β)and IL-18 as well as the induction of an programmed cell death called pyroptosis.The sensing of exogenous DNA by AIM2 has great significance in the host defense of pathogenic microorganism including bacteria,virus fungi and parasites.This article will focus on the research progress of the mechanism of AIM2 inflammasome in infection.