海南省女性HPV疫苗相关知识和接种意愿调查

Awareness of human papillomavirus vaccine knowledge and willingness to receive human papillomavirus vaccination among women in Hainan Province

目的了解海南省女性人乳头瘤病毒(HPV)疫苗知识知晓水平,以及为自己和女儿接种HPV疫苗的意愿,为HPV疫苗推广和宫颈癌防治提供参考。方法于2021年7月—2022年2月,选择海南省20~64岁参加宫颈癌筛查项目的女性为调查对象,通过问卷调查收集人口学信息、HPV疫苗相关知识知晓情况,以及为自己和女儿接种HPV疫苗的意愿;采用多因素logistic回归模型分析HPV疫苗接种意愿的影响因素。结果发放问卷4300份,回收有效问卷4023份,回收有效率为93.56%。调查对象年龄为(35.52±6.48)岁,其女儿年龄为(8.93±4.83)岁。知晓HPV疫苗相关知识826人,知晓率为20.53%。为自己和为女儿接种HPV疫苗意愿率分别为75.07%和71.36%。多因素logistic回归分析结果显示:年龄(20~<30岁,OR=1.474,95%CI:1.167~1.862;30~<40岁,OR=1.455,95%CI:1.199~1.765)、城市户籍(OR=1.251,95%CI:1.016~1.541)、家庭人均月收入(3000~<5000元,OR=1.568,95%CI:1.314~1.873;≥5000元,OR=1.231,95%CI:1.014~1.496)、自费接种HPV疫苗单剂次可负担费用(100~<500元,OR=1.358,95%CI:1.159~1.590;≥500元,OR=1.609,95%CI:1.188~2.180)和知晓HPV疫苗相关知识(OR=4.473,95%CI:3.416~5.855)是调查对象为自己接种HPV疫苗意愿的影响因素;参加新农合(OR=1.652,95%CI:1.087~2.511)、接种HPV疫苗单剂次可负担费用(100~<500元,OR=1.905,95%CI:1.633~2.221;≥500元,OR=1.683,95%CI:1.275~2.223)、知晓HPV疫苗相关知识(OR=3.625,95%CI:2.847~4.615)、女儿主动要求接种HPV疫苗(OR=1.695,95%CI:1.293~2.222)和对女儿进行性健康教育频率(经常,OR=2.142,95%CI:1.789~2.564;偶尔,OR=1.707,95%CI:1.416~2.059)是为女儿接种HPV疫苗意愿的影响因素。结论海南省20~64岁女性HPV疫苗相关知识知晓率较低,为自己/女儿接种HPV疫苗意愿主要与年龄、户籍、经济水平、疫苗价格和是否知晓HPV疫苗相关知识等有关。

Objective To investigate the awareness of human papillomavirus(HPV)vaccine knowledge among women in Hainan Province and the willingness to receive HPV vaccination among women and their daughters,so as to provide in⁃sights into HPV vaccine promotion and cervical cancer control.Methods Women aged 20 to 64 years who participated in the cervical cancer screening program in Hainan Province from July 2021 to February 2022 were enrolled,and par⁃ticipants'demographics,awareness of knowledge about HPV vaccine,and willingness to receive HPV vaccination among themselves and their daughters using a questionnaire survey.The factors affecting willingness to receive HPV vaccina⁃tion were identified using a multivariable logistic regression model.Results A total of 4300 questionnaires were allo⁃cated and 4023 valid questionnaires were recovered,with an effective recovery rate of 93.56%.The respondents had a mean age of(35.52±6.48)years,and their daughters had a mean age of(8.93±4.83)years.There were 826 participants knowing HPV vaccine-related knowledge,with an awareness rate of 20.35%.The proportions of willingness to receive HPV vaccination were 75.07%among respondents and 71.36%among their daughters.Multivariable logistic regres⁃sion analysis identified age(20 to<30 years,OR=1.474,95%CI:1.167-1.862;30 to<40 years,OR=1.455,95%CI:1.199-1.765),urban-registered residence(OR=1.251,95%CI:1.016-1.541),monthly household income(3000 to<5000 Yuan,OR=1.568,95%CI:1.314-1.873;5000 Yuan and more,OR=1.231,95%CI:1.014-1.496),affordable fees for a single dose of HPV vaccination(100 to<500 Yuan,OR=1.358,95%CI:1.159-1.590;500 Yuan and high⁃er,OR=1.609,95%CI:1.188-2.180),and awareness of HPV vaccine-related knowledge(OR=4.473,95%CI:3.416-5.855)as factors affecting respondents'willingness to receive HPV vaccination,and participation in New Rural Cooper⁃ative Medical Insurance(OR=1.652,95%CI:1.087-2.511),affordable fees for a single dose of HPV vaccination(100 to<500 Yuan,OR=1.905,95%CI:1.633-2.221;500 Yuan and higher,OR=1.683,95%CI:1.275-2.223),awareness of HPV vaccine-related knowledge(OR=3.625,95%CI:2.847-4.615),daughter's active request for HPV vaccination(OR=1.695,95%CI:1.293-2.222),and frequency of sexual health education for daughters(frequently,OR=2.142,95%CI:1.789-2.564;occasionally,OR=1.707,95%CI:1.416-2.059)as factors affecting the willingness to receive HPV vaccina⁃tion among respondents'daughters.Conclusions The awareness of HPV vaccine-related knowledge is low among women aged 20 to 64 years in Hainan Province,and the women's and their daughters'willingness to receive HPV vaccination is associated with age,household registration,economic level,price of HPV vaccine and awareness of HPV vaccine-related knowledge.