胞葬作用与炎症相关性疾病的研究进展

Research progress on the relationship between efferocytosis and inflammation-related diseases

胞葬作用是机体内吞噬细胞清除凋亡细胞的生理过程。完整有效的胞葬作用对维持机体内环境稳态至关重要。而胞葬作用功能障碍会导致凋亡细胞清除不足,继而触发细胞次级坏死和促炎因子释放,引起组织炎症应答和自身免疫反应。因此,胞葬作用功能障碍是许多慢性炎症性疾病和自身免疫性疾病的重要发病基础。本文综述了胞葬作用的具体分子机制及其功能受损在动脉粥样硬化和系统性红斑狼疮等炎症相关性疾病中的研究进展,以期为炎症相关性疾病的防治提供新的治疗策略和理论依据。

Efferocytosis is a physiological process by which phagocytes remove apoptotic cells.Effective efferocytosis is essential for the maintenance of tissue homeostasis.However,defective efferocytosis may cause insufficient clearance of apoptotic cells,then trigger secondary cell necrosis and release of pro-inflammatory factors,resulting in tissue inflammatory response and autoimmune reaction.Accordingly,defective efferocytosis underlies many chronic inflammatory diseases and autoimmune diseases.This review summarizes the recent research progress concerning the molecular mechanisms of efferocytosis and defective efferocytosis in inflammation-related diseases,such as atherosclerosis and systemic lupus erythematosus,in order to provide new therapeutic strategies and theoretical evidence for the prevention and treatment of inflammation-related diseases.