抗菌药物致肝脏毒性的研究进展

Research Progress of Antimicrobial Agents Induced Hepatotoxicity

药物性肝损伤(DILI)是指各类药物及其代谢产物和辅料等所诱发的肝损伤,是临床药源性疾病之一。在DILI相关研究中,抗菌药物是最为常见的药物类型。随着抗菌药物在临床上日益广泛应用,抗菌药物相关性肝损伤事件发生也不断增加,严重时可危及生命。本文通过对不同类型抗菌药物致肝脏毒性的机制及临床特点等相关研究进行综述,旨在深入了解抗菌药物致肝脏毒性的机制,为加强抗菌药物致肝损伤的防治及临床安全合理应用提供参考。

Drug-induced liver injury(DILI) is a clinical drug-induced disease induced by various drugs and drug metabolites and excipients. In DILI related studies, antibacterial drugs are the most common type of drugs.With the increasing use of antibacterial drugs in clinical practice, the incidence of liver injury related to antibacterial drugs is also increasing, which can endanger life in serious cases. This article reviews the mechanism and clinical characteristics of liver toxicity caused by different types of antibacterial drugs, aiming to deeply understand the mechanism of liver toxicity caused by antibacterial drugs, and provide reference for strengthening the prevention and treatment of liver injury caused by antibacterial drugs and clinical safe and reasonable application.