DNA-PKcs抑制剂在胶质母细胞瘤治疗中的作用与前景

Role and prospect of DNA-PKcs inhibitors in treatment of glioblastoma

胶质母细胞瘤是人类中枢神经系统肿瘤中恶性程度最高、预后最差的一类肿瘤,尽管目前对于胶质母细胞瘤可采取手术、辅助放射、化学药物等治疗方式,其预后仍然较差。新的起源学说认为胶质母细胞瘤中的胶质瘤干细胞可能起源于脑室下区,并且与该区的神经干细胞相关。而这种具有干细胞特性的肿瘤细胞与其他干细胞一样,拥有极强的DNA损伤修复能力,并且可以通过这种DNA损伤修复作用来增强肿瘤对于放射治疗的顽固抗性。该文探讨通过抑制DNA损伤修复的关键酶来拮抗胶质母细胞瘤的放疗抗性,提高患者预后的可能性。

Glioblastoma(GBM)is a type of human central nervous system tumor with the highest degree of malignancy and the worst prognosis.Although GBM is currently treated with surgical treatment,adjuvant radiotherapy,and chemotherapy,it still has a poor prognosis.At present,the new theory of origin believes that glioma stem cells in GBM may originate from the subventricular zone and are associated with the neural stem cells in this zone.Such tumor cells with stemness,like other stem cells,have a strong ability for DNA damage repair and can thus enhance the resistance of tumor to radiotherapy.This article describes the strategies for GBM against radiotherapy through the ability of glioma stem cells for DNA damage repair and explores the possibility of antagonizing GBM radiotherapy resistance by inhibiting key enzymes for DNA damage repair,so as to improve patient prognosis.