上皮间质转化与胶质瘤侵袭迁移的研究进展

Research advances in epithelial-mesenchymal transition and the invasion and migration of glioma

胶质瘤是一种恶性程度高、浸润性生长的颅内原发性肿瘤。肿瘤的侵袭和转移是导致患者预后差的主要原因。上皮细胞-间质细胞转换(EMT)是胶质瘤细胞获得高度迁移和侵入表型特征的关键过程。EMT是一个进化上保守的细胞发育程序,和致癌效应密切相关。该文就EMT与胶质瘤侵袭迁移相关作用机制和靶向治疗进行综述,为胶质瘤的诊疗研究提供理论依据。

Glioma is a highly malignant and invasive intracranial primary tumor,and tumor invasion and metastasis is the main cause of poor prognosis.Epithelialmesenchymal transition(EMT)is the key process for glioma cells to obtain the phenotypic characteristics of strong migration and invasion abilities.As an evolutionarily conserved cellular development process,EMT is closely associated with carcinogenic effect.This article reviews the mechanism of action of EMT in the invasion and migration of glioma and related targeted therapy,so as to provide a theoretical basis for the diagnosis and treatment of glioma.