孕妇维生素D缺乏对子代肥胖影响的研究进展

The advance of the effect of vitamin D deficiency in pregnant women on their offspring in obesity

维生素D(VD)在人体生长发育和生理代谢过程中具有重要作用。目前,全球VD缺乏人数众多。其中,妊娠期妇女更容易发生VD缺乏。大量临床证据和实验研究表明,孕妇VD缺乏可能导致子代新生儿期、儿童期肥胖的发生风险升高,其机制可能涉及脂肪代谢过程异常、胰岛素抵抗、炎症反应激活、肠道菌群紊乱、氧化应激等。故重点探讨孕妇VD缺乏对子代脂代谢相关生理指标异常的影响及其潜在机制,旨在为肥胖相关机制研究以及生命早期干预提供科学依据。

Vitamin D(VD) plays a key role in growth and metabolism. Vitamin D deficiency is a common problem worldwide,especially in pregnant women. With strong clinical evidence and well-documented experimental research,vitamin D deficiency in pregnant women may lead to a cumulative risk of obesity in their offspring’s neonatal and childhood periods. Its mechanisms are supposed to be relevant to abnormal fat metabolism,insulin resistance,increased inflammatory responses,gut microbiota dysfunction,and oxidative stress. This review focuses on the effects of maternal vitamin D deficiency on the abnormal physiological indicators related to lipid metabolism among offspring and its potential mechanisms,aiming to give robust evidence for further studies of obesity mechanisms and early life interventions.